What is in this document
A market growing steadily, not a spike
A competitor is anything she might buy instead of our product, whatever is in it. Suppositories and inserts are the closest comparison because they share a format and a decision. Around them sit the moisturisers, the supplements, the newer non hormonal drugs, and the prescriptions themselves, whether she gets one from her own physician or gynaecologist in a consulting room or from a telehealth service without ever seeing anyone.
The numbers are good. Seventy five million American women are in perimenopause, menopause or postmenopause, and roughly six thousand more reach menopause every day. Vasomotor symptoms affect up to eighty per cent of women. Among those with frequent symptoms the median duration is seven point four years, four and a half of them after the final period. Genitourinary symptoms are reported by a quarter to four fifths of postmenopausal women depending on how the question is asked, and unlike hot flushes they are progressive.
The money has been building steadily rather than arriving. One point seven billion dollars went into menopause across the six years from 2020 to 2025. The share of very large American employers offering a menopause benefit went from twenty eight per cent in 2024 to fifty eight per cent in 2026, across employers covering nearly twelve million lives. Ulta lists more than fifty products in its menopause category. The direction is consistent and the rate is increasing, which is a better reason to enter than a spike would be.
The largest single alternative to us is not a product at all. It is the prescription her own physician writes, and that route is growing. The FDA moved to remove the boxed warnings from hormone therapy in November 2025 and approved the first revised labels in February 2026, and prescribing has roughly doubled since 2017. Most of this category has read that as bad news for anything positioned as an alternative. It matters here because it means the consulting room is a live competitor, not a legacy one.
And the field is emptier than it looks from inside it. Mayo Clinic surveyed nearly five thousand American women aged forty five to sixty and found eighty seven per cent had not sought medical care for their symptoms, with only about one in four receiving any treatment. The category is loud to us because we stare at it all day. To her it is close to silent.
She already accepts a wider range than this category assumes
On any given afternoon she can weigh a prescription, a supplement, a moisturiser and a vaginal insert against each other, at anything from seven dollars a month to six hundred and fifty. Format is not her obstacle and an unfamiliar ingredient is not her obstacle. Both are already normal to her in this aisle.
| What she could choose | Examples | Per month | What it does for her |
|---|---|---|---|
| Prescription vaginal oestrogen | Vagifem, Yuvafem, Imvexxy, Estrace cream | $20 to $65 | Treats vaginal dryness and painful sex directly. Written by her own physician or gynaecologist, and it requires a decision about hormones. |
| Prescription non hormonal | Intrarosa, Osphena, Veozah, Lynkuet | $35 to $650 | Effective and expensive, and also written in a consulting room. Veozah carries a boxed warning for liver injury and needs six liver tests in the first year. Lynkuet has no boxed warning but requires liver testing and carries a daytime impairment warning. |
| Telehealth subscriptions | Alloy, Wisp, Midi, Interlude, Hers | $20 to $40 | The same prescriptions as the two rows above, obtained without a consulting room and without insurance. This is the price anchor most women now carry in their heads. |
| Premium non hormonal inserts | Bonafide Revaree, Hyalo Gyn, Replens | $16 to $65 | Hyaluronic acid or polymer moisturisers. Comfort, not regulation. Revaree is the price leader of this tier. |
| Oral menopause supplements | Thermella, Relizen, Equelle, Estroven, Amberen | $18 to $60 | Botanical and nutraceutical. Swallowed, so subject to first pass metabolism and low absorption. |
| Vaginal wellness suppositories | Boric acid, probiotic and botanical inserts | $7 to $40 | Cheap, high volume, mostly aimed at odour and infection rather than hormonal transition. |
| Cannabinoid suppositories | Foria, Hello Again, Vella, MedRoots, Octavia, EntheaCare | $40 to $55 | The nearest direct comparison. All but one are vaginal. None publishes more than four cannabinoids. |
| Well Woman Collective | Transition and Cycle | $99 | Ten cannabinoids, 170 mg per unit, fifteen units, rectal by design. Support for the body's own regulation rather than replacement of it. |
Our nearest comparison is six brands, all but one of them vaginal, none publishing more than four cannabinoids, all priced between forty and fifty five dollars a month. That band is what this category has decided the product is worth, and it was set by boxes carrying a fifth of the material ours does. We price above it, so the band is the number we have to argue with.
Nine brands, and the ones standing next to them
Nine brands sell a cannabinoid suppository to American women. Two of them publish no milligram figure at all, two reach her through dispensaries rather than direct, and no two lead with the same thing. This is who each one is.
| Brand | What it sells | Route | Where she buys it | What it leads with |
|---|---|---|---|---|
| Foria | Relief Melts, Booty Melts, Intimacy Melts | Vaginal and rectal, depending on the product | Direct | Cannabis kept as heritage at the brand layer and explicit at the product layer. The only brand in the category with a rectal specific product of its own. |
| Hello Again | Mind, Body and Sleep suppositories | Vaginal | Dispensaries and direct | CBD in the page title. It sells through dispensaries, where the cannabis association qualifies rather than disqualifies. Hormone free is the headline. |
| Vella | Ebbtide | Vaginal | Direct | The team that developed Viagra and Cialis. CBD and hemp have been removed from the homepage entirely and replaced with that credential. |
| MedRoots | Wellness Plus, Wellness Daily, Vaginal Moisturizer | Vaginal or rectal | Direct | A menopause bundle labelled for either route, with magnesium and hyaluronic acid alongside the cannabinoid. |
| Octavia | One suppository | Vaginal or rectal | Direct | Price. One hundred and fifty milligrams for twenty two dollars, across four units, which is roughly a week. |
| EntheaCare | YoniEase | Vaginal or rectal | Direct | Full spectrum with named terpenes. The widest published cannabinoid profile in the category, at four. |
| Upstate Mary | Hunter | Vaginal or rectal | Direct | Full spectrum, with neither a milligram figure nor a pack count published anywhere on the site. |
| Healing Essence | A rectal suppository for pelvic pain | Rectal | Direct | Pelvic pain rather than hormonal transition. Not sold as a menopause product. |
| Treehouse Cannabis | Suppositories | Vaginal or rectal | Dispensaries | A cannabis brand with a suppository in the range rather than a women's health brand. |
The brands standing next to them, which set the price and the tone
She does not shop in a cannabinoid aisle. The brands that shape what she expects a women's health product to cost, to promise and to look like are mostly not cannabinoid brands at all.
Bonafide is the commercial proof that the unglamorous end of this category is where the money is. It sold to Pharmavite for four hundred and twenty five million dollars as the least charming brand in the field, leads with a hormone free badge, and explains neurokinin receptors to its customers without anyone deciding it is in the receptor business. Midi Health was valued at a billion dollars on prescriber authority rather than brand charm.
Alloy, Evernow and Stripes carry near identical wording on the care you deserve. Womaness uses we see you, we hear you as a brandline. Elektra Health uses smashing the taboo as its. Kindra runs a badge stack, Joylux uses confidence restored, and Phenology's entire visual identity was built by Pentagram from the idea that menopause is another chapter in your life, illustrated with butterflies for transformation.
Telehealth is where the price anchor comes from. Alloy, Wisp, Midi, Interlude and Hers deliver a prescription to the door for twenty to forty dollars a month without insurance. That is the number most women in this market now carry in their heads, and it was not set by anyone selling a suppository.
Dose, pack and cost per milligram
List prices, not promotional, taken from each brand's own product pages. The pack price is the number a brand advertises. The number that decides value is what she receives for it and how much of a month it covers.
| Product | Route | Extract type | Cannabinoids | Per unit | Units | Per pack | Total mg | Cost per mg |
|---|---|---|---|---|---|---|---|---|
| Well Woman Collective | Rectal | Broad spectrum plus isolates | 10 | 170 mg | 15 | $99 | 2,550 mg | $0.039 |
| Foria Relief Melts | Vaginal or rectal | Broad spectrum | 1 | 100 mg | 8 | $50 | 800 mg | $0.063 |
| Foria Booty Melts | Rectal | Broad spectrum | 2 | 150 mg | 4 | $34 | 600 mg | $0.057 |
| Hello Again | Vaginal | Hemp extract, type not stated | 2 | Not published | 10 | $55 | Not published | Cannot be calculated |
| Vella Ebbtide | Vaginal | Isolate | 2 | 100 mg | 8 | $40 | 800 mg | $0.050 |
| MedRoots Wellness Plus | Vaginal or rectal | Full spectrum | 1 | 100 mg | 10 | $59.95 | 1,000 mg | $0.060 |
| Octavia | Vaginal or rectal | Not stated | 1 | 150 mg | 4 | $22 | 600 mg | $0.037 |
| EntheaCare YoniEase | Vaginal or rectal | Full spectrum | 4 | 55.5 mg | 8 | $48.95 | 444 mg | $0.110 |
| Upstate Mary Hunter | Vaginal or rectal | Full spectrum | 0 | Not published | Not published | $20 | Not published | Cannot be calculated |
Six of the eight priced products sit between three point seven and six point three cents a milligram. EntheaCare sits outside that at eleven cents. Two brands publish no milligram figure and cannot be placed on the scale at all. The cheapest is Octavia, on a four unit pack of a single cannabinoid that covers about a week. Nobody in the category delivers more than one thousand milligrams in a pack.
What each brand tells a woman is inside
Disclosure is the one axis in this category that can be compared without argument. Either a brand names a cannabinoid and puts a milligram figure against it, or it does not. This is what every brand publishes on its own product pages.
| Product | Extract type | Published breakdown | Named | Other actives |
|---|---|---|---|---|
| Well Woman Collective Transition and Cycle | Broad spectrum crystal resistant distillate with added isolates | Ten cannabinoids, every one named: CBD, CBG, CBN, CBC, CBDA, CBGA, CBDV, CBE, CBL and CBTC. THC not detected. Individual milligram figures are on the certificate that ships with her box, matched to her lot number. We publish the profile and the total. We do not publish the split, because the split is the formulation. | 10 | MCT, cocoa butter |
| Foria Relief Melts | Broad spectrum | 100 mg CBD. No other cannabinoid quantified. | 1 | None |
| Foria Booty Melts | Broad spectrum | 150 mg CBD and CBG combined. The split between the two is not published. | 2 | Jojoba oil |
| Foria Intimacy Melts | Broad spectrum | 50 mg CBD. No other cannabinoid quantified. | 1 | None |
| Hello Again Mind, Body, Sleep | Hemp extract, under 0.3 per cent THC. Type not stated. | No milligram figure published anywhere on the product pages or the FAQ. Cannabinoid pairs named only: CBD with CBC, CBG or CBN. | 2 | Botanical blends, avocado oil, vitamin E |
| Vella Ebbtide | Isolate. CBD plus CBDA. | 75 mg CBD · 25 mg CBDA. Fully broken down, and the best disclosure among the competitors. | 2 | None |
| MedRoots Wellness Plus | Full spectrum | 100 mg total. Individual cannabinoids not quantified. | 1 | Magnesium 25 mg |
| MedRoots Wellness Daily | Isolate, THC free | 50 mg CBD. | 1 | Magnesium 25 mg |
| MedRoots Vaginal Moisturizer | Isolate | 30 mg CBD. | 1 | Hyaluronic acid 5 mg, magnesium, aloe, vitamins A and E |
| Octavia | Type not stated | 150 mg CBD. | 1 | None published |
| EntheaCare YoniEase | Full spectrum | 50 mg CBD · 2.7 mg CBC · 1.4 mg CBG · 1.4 mg THC. Broken down, and the widest profile any competitor publishes. | 4 | Named terpenes |
| Upstate Mary Hunter | Full spectrum | Neither milligrams nor pack count published anywhere on the site. | 0 | None |
Only two competitors in the entire category publish a cannabinoid breakdown at all. Vella publishes two. EntheaCare publishes four. Everyone else gives a single total or, in two cases, nothing whatsoever. That is the state of disclosure in a category selling into a body.
The category has one house style and it has been documented
The sense that these brands all look and sound alike is not a matter of taste. It is a documented failure mode with a name attached, and the people who work in this category say it out loud.
The problem is old enough to have been documented for a decade. NPR reported on it in 2015, quoting Dr Wulf Utian on the organisations and, in his words, snake oil salesmen climbing on the bandwagon, and Dr Janet Pregler on the reflex to sell this to as many people as possible. The same piece records the reaction that should worry any brand built on symptom maximising, from a woman who said she thought there was something wrong with her because she was not having terrible symptoms.
The look is not accidental either. Fast Company has codified the menopause house style: vibrant colour, organic shapes, hand drawn illustration, a friendly serif and a refined wordmark, naming Alloy, Evernow, Stripes, Phenology and Womaness. Pentagram's account of designing Phenology describes starting from the idea that menopause is another chapter in your life, and the illustration system uses butterflies for transformation.
The messaging has been classified. Academic analysis of twenty menopause advertisements published between 2019 and 2024 found three repeating instructions: defy it, disavow it, embrace it. All three put the burden on the individual woman and restate the same idea about how she is supposed to look.
The commercial version has a name in the trade press. Menowashing. Put the word meno in front of a product and the price can double, which is how menopause shampoo and menopause chocolate came to exist. The part that matters is the second half of it. People can see through it.
What she wants has been measured, and the American data is clear. AARP finds that sixty six per cent of people over fifty prefer brands featuring mixed ages, seventy three per cent prefer brands catering to all ages rather than only to older people, and seventy two per cent of women prefer age diverse advertising. Being spoken to as a separate category is itself part of what she objects to.
Hone Health asked a thousand American adults aged thirty five to sixty five which words they would abolish. Old came first by a distance. Midlife made the top ten. The number underneath matters more: only a fifth of the objection is about appearance, and over sixty per cent is about identity, energy and mattering. Seventy three per cent feel positive about this stage of life and seventy one per cent think their best years are now or ahead.
Phrases that are spent, and who has them
| Phrase | Already used by | Why it is spent |
|---|---|---|
| The care you deserve | Midi, Evernow, Stripes, near identical wording on all three | A promise about her rather than about the product, in near identical words from three brands at once. |
| Your next chapter | Pentagram, as the stated design rationale for Phenology | Life stage narration. An entire visual identity was built on this one line. |
| Embrace this season | Named as a studied failure mode in peer reviewed analysis of twenty menopause campaigns | Named in peer reviewed analysis as one of three repeating instructions that all put the burden on the woman. |
| We see you, we hear you | Womaness, as a brandline | Empathy as a brandline. Every brand in the category says a version of it. |
| Smashing the taboo | Elektra Health, as its brandline | An announcement that a taboo is being broken, standing in for breaking it. |
| Feel like yourself again | Joylux, adjacent to its confidence restored | Assumes she has lost herself. The survey data says most women do not accept that premise and resent it. |
| Anti ageing | Abandoned across the whole beauty industry, and never used by Stripes as policy | Dead. Using it now dates a brand by four years. |
| Natural | One of the conditions that lets menowashing happen, because it implies safe without saying anything | Implies safe without stating anything. One of the conditions that lets menowashing happen. |
| The change | Nobody. It has disappeared from live sites entirely. | Gone. It has disappeared from live sites entirely. |
The five words the category fights over
Menopause. The evidence points two ways and both are right, because they measure different surfaces. Shoppers say they want to be able to find products labelled for menopause, and that brands do not signpost them well enough. Interviews with menopausal women aged forty nine to sixty one found the opposite reaction to being targeted explicitly: isolation, discomfort, and fear that public association with menopause exposes a stigmatised identity, with some women rejecting brands to keep their anonymity. It is a search word and a shelf word. It is not a bathroom cabinet word.
Hormone free. The entry ticket, not a differentiator. It is Bonafide's lead badge, Hello Again's headline, Kindra's badge stack and Joylux's descriptor. Four competitors have already built on it.
Wellness. Devalued but not toxic. Usable as a category descriptor and unusable as a promise. The whole menowashing criticism is, at bottom, a wellness credibility crisis.
Cannabinoid, hemp and CBD. Three live strategies, and they produce three different companies. Foria keeps cannabis as heritage at the brand layer and explicit at the product layer. Hello Again leads with CBD in the page title because it sells through dispensaries, where the association qualifies rather than disqualifies. Vella has removed CBD and hemp from its homepage entirely and replaced the credential with the fact that its team developed Viagra and Cialis.
Old, midlife, and every word for decline. Hone Health put old first among words people want abolished and midlife in the top ten, and found the objection is about mattering rather than looks.
Five gaps, each one verified by absence
Every item here is a thing no brand in the category currently does. Each was established by looking for it on every live site and not finding it, which is a weaker kind of evidence than a citation and a stronger kind than an opinion.
1. Nobody is rectal by design.
Three brands offer the rectal route. Healing Essence sells a rectal suppository for pelvic pain, MedRoots labels a menopause bundle for either route, and Treehouse sells through dispensaries. In all three the route is a second line on a label, offered as an alternative to the vaginal use the product was designed around. No brand has built its product, its dose or its argument on the route, and none publishes a reason for choosing it.
2. Nobody publishes a real breakdown.
Eleven competitor products across seven brands. Two publish a cannabinoid breakdown: Vella, with two, and EntheaCare, with four. Everyone else publishes a single total. Hello Again publishes no milligram figure anywhere on its product pages or FAQ. Upstate Mary publishes neither milligrams nor pack count.
3. The whole category is built on one molecule.
Every competitor sells cannabidiol, or cannabidiol with one companion. On the published screen of phytocannabinoids across the TRP channels, cannabidiol has no published agonist activity at TRPV4 at all, and at TRPV1 it is a partial agonist of modest potency that desensitises the channel faster than it activates it on sustained exposure. The compounds that reach TRPV4 are CBG, CBGA and CBN. The most potent and most selective at TRPA1 is CBC. No brand in this category carries those at any meaningful quantity, so the category as it stands leaves named channels untouched.
4. Nobody publishes a limitation.
No brand in the category states what it does not know, what has not been tested, or where its evidence stops. Not one product page carries a caveat about its own claims. This is the cheapest differentiator available in the field and it is completely unoccupied.
5. Nobody is talking to the eighty seven per cent.
Mayo Clinic found eighty seven per cent of symptomatic American women aged forty five to sixty had never sought care, and about one in four are receiving any treatment. Every brand in the category is competing for the woman who has already decided she has a problem worth spending on. The larger group has been left alone.
The opening is not a better version of the category look. It is to compete on the axis the category has abandoned. Everyone else sells a feeling about a life stage. Nobody sells a specified quantity of a named material with a certificate that matches the box.
Three numbers, and one rule about using them
170 mg a unit. Ten cannabinoids. 2,550 mg a month.
170 mg per unit is the highest cannabinoid load of any women's health suppository sold in the United States. The nearest is 150 mg.
Ten cannabinoids is two and a half times the widest profile anyone else publishes, which is EntheaCare's four. Two of our competitors publish nothing at all.
2,550 mg per pack is more than three times what the category leader delivers in a month, at twice the price. We are within a fifth of a cent of the cheapest per milligram in the category, and the product that undercuts us is a four unit pack of a single cannabinoid.
We are also the only brand in the field that publishes ten cannabinoids by name, and the only one that will ship a certificate matched to her lot number. We publish the profile and the total. We do not publish the split, because the split is the formulation.
None of this goes to a customer. She may never have heard of the others, and naming them gives her a list to go and check. Everything in this document is an argument for an investor, a partner or a practitioner. On a product page the only comparison is to what she is already doing.
Teach the system, then sell the product
Sections 5, 6 and 7 all point the same way. No brand in this category explains why its product should work. They name an ingredient and describe a feeling. The endocannabinoid system is the mechanism underneath our formulation, almost nobody has heard of it, and nobody in the field is teaching it. That is the largest unoccupied position in this market and it is the one I think we take.
The argument is simple enough for a customer. The endocrine system produces the hormones. It does not work in isolation, and one of the systems alongside it is the endocannabinoid system, whose job is to hold things steady. Mood, sleep, temperature, stress, and in women the monthly and life stage rhythms. It works through receptors found almost everywhere in the body and the body makes its own compounds to switch them on and off.
The reason she has never heard of it is a matter of record. It was identified in the early 1990s, after most practising doctors finished training. It is one of the most widespread receptor networks in the human body and it is missing from the education of the people she asks for advice. That is not a marketing angle. It is a genuine gap in what she has been told, and filling it is the most useful thing we can do for her before she has bought anything.
There is precedent in her own aisle. Bonafide explains neurokinin receptors to its customers and sold for four hundred and twenty five million dollars. Nobody decided Bonafide was in the receptor business. Teaching the mechanism did not narrow the brand. It gave the product a reason to exist that a competitor could not copy by changing a label.
Why this works specifically against this field
1. It answers the question the category refuses to answer.
Eleven competitor products and not one explains a mechanism. They sell cannabidiol as an ingredient with a mood attached. A woman who asks why this should work gets nothing back. We can answer her in four sentences, and answering her is what earns the rest of the sale.
2. It makes the ten cannabinoids mean something.
Ten is a bigger number than one and on its own that is a weak argument. Once she understands there is a receptor network with many different targets, ten named compounds reaching different parts of it is the obvious thing to want and one compound is the obvious thing to question. The education is what converts our specification from a boast into a reason.
3. It moves us off the price band.
Section 4 puts the category between forty and fifty five dollars a month. We cannot win that comparison as a better suppository. We can win it as a different proposition, and the proposition is support for the system that helps regulate her hormones rather than a product for a symptom.
4. It reaches the eighty seven per cent.
Every brand in the field is competing for the woman who has already decided she has a problem worth spending on. Education reaches the much larger group who have not, because it costs her nothing to read and it does not require her to accept a diagnosis first.
Support the system that helps regulate the hormones, rather than supplying the hormones.
Nobody in the category is making this proposition clearly. It is not an alternative to hormone therapy and it is not competing with it. For the woman who has decided against hormones, it is not a compromise. It is the thing she could not find.
Three ways to build on it, and what each one asks of us
The education is the front of the business. A woman arrives, learns what the endocannabinoid system is in four minutes, and the product is the thing she reaches for once she understands it. The site is built around explanation rather than around a product grid, and most of what we publish is free.
What it asks of us
Real writing, regularly, and the patience to sell on the second visit rather than the first. It is the slowest of the three to convert and the hardest for a competitor to copy, because copying it means writing it.
Disclosure is the position. Ten cannabinoids named, the total published, the certificate matched to her lot number in the box, and the limitations stated in our own words before anyone else states them. Section 5 shows only two of the eleven competitor products publish a breakdown at all, and section 7 shows not one publishes a limitation.
What it asks of us
The certificates have to exist before the claims do. This direction cannot be announced and then built. It is also the cheapest of the three, because the work is already part of manufacturing.
Rectal by design, argued rather than offered. Eight of the nine brands sell a vaginal product and the three that mention the rectal route treat it as a second line on a label. The reasoning for the route is real, it is defensible, and no competitor has published a reason for choosing either route.
What it asks of us
Saying the word in public, and the Lactobacillus panel, which turns the argument from a reasoned choice into a citation nobody else owns.
These are not alternatives. Direction 2 is the evidence that makes Direction 1 believable, and Direction 1 is what makes Direction 3 sound like a decision rather than an oddity. The order matters more than the choice. Teach the system, prove the box, then explain the route.
The education has to stop where the evidence stops. We can say the endocannabinoid system works alongside the endocrine system to hold things steady, because that is what it does. We cannot say our product regulates her endocrine system, and the compliance standard does not allow it. The line is support for a system, never treatment of one.
And the obvious version of this story is wrong. The intuitive teaching point would be that endocannabinoids decline at menopause and we top them up. The published human data goes the other way. Circulating endocannabinoid levels rise around and after menopause, in two separate datasets, one of 184 women and one covering 700 across the lifespan. What is established is that her hormones change and the system alongside them measurably moves with them. Something is happening there. Build the teaching on that, not on a depletion story a careful reader can disprove in one search.
What the field forces us to decide
These are the decisions the competitor picture makes urgent. They are not the whole decision list.
Decide where the cannabinoid sits.
Foria's answer, Hello Again's answer and Vella's answer are three different companies with three different customers. Vella removed the word from its homepage and replaced it with a pharmaceutical credential. That is the most instructive move any competitor has made and it was made by the brand with the best disclosure in the category.
Get the certificates before the claims.
Our entire separation from this field is disclosure. One hundred and seventy milligrams and the total THC figure are currently design positions rather than test results. A brand whose whole position is publishing what is in the box cannot publish a number it has not measured.
Decide whether the price band is one we join or one we ignore.
The category has settled between forty and fifty five dollars a month on a fifth of the material. Ninety nine dollars is defensible on cost per milligram and indefensible on shelf price alone. That argument has to be won on the page or the price has to change.
Commission the Lactobacillus panel.
Eight of the nine brands sell a vaginal product. The question of what a cannabinoid does to vaginal lactobacilli is unanswered in the literature and unasked by the category. A few weeks of standard broth microdilution turns our route decision from a reasoned choice into a citation nobody else owns.
Resolve the total THC ceiling before 12 November 2026.
The 0.4 milligram total THC per container rule takes effect in two months and applies to every full spectrum product in the table above, not only to ours. It will move some of these brands off the shelf. Knowing which ones is worth the work.
What each one acts on, and what that target governs
Six cannabinoids are added deliberately to the formulation, on top of the broad profile the distillate carries. Every competitor product in section 5 is cannabidiol, or cannabidiol with one companion. This is the published receptor pharmacology for what we add and they do not.
| Cannabinoid | Where it acts | What that could mean for her |
|---|---|---|
| CBD | Negative allosteric modulator at CB1. Also 5-HT1A, TRPV1, PPAR gamma. | 5-HT1A is the serotonin receptor that anxiety medicines are built around, and PPAR gamma governs how the body handles inflammatory signalling. The everyday version of that is steadier mood and less of the low grade ache and stiffness that builds through the transition. Because CBD moderates CB1 rather than switching it on, it does not intoxicate. |
| CBDA | Acts at 5-HT1A roughly a thousand times more strongly than CBD in receptor binding assays. Also PPARs, TRPV1 and selective COX-2. | Reaches the same serotonin receptor as CBD, far more strongly. That is the pathway most associated with nausea and with mood. COX-2 is the enzyme anti inflammatory drugs act on, so this is the discomfort end of the formulation. |
| CBG | Alpha-2 adrenoceptor agonist, 5-HT1A antagonist, TRPV1 to 4 and TRPA1, PPAR gamma. | Alpha-2 is the adrenaline receptor, and it is the target of clonidine, prescribed off label for hot flushes. CBG also reaches all four TRPV channels and TRPA1, which are how the body senses heat, pressure, stretch and irritation. Temperature and physical comfort. |
| CBGA | PPAR alpha and gamma, aldose reductase. | The two PPARs govern how the body handles fat, energy and inflammatory signalling, and aldose reductase is part of glucose handling. This is the metabolic end, the side of the transition that shows up as weight and energy rather than as symptoms she can point to. |
| CBN | CB1 and CB2, and a strong TRPA1 agonist. | One of the few that binds both cannabinoid receptors directly rather than modulating from the side. CB2 sits on immune cells, which is the inflammatory compartment. Strong at TRPA1, the irritation sensor. Settling, and the inflammatory side of discomfort. |
| CBC | Partial CB2 agonist, strong TRPA1, TRPV3 and 4, anandamide reuptake inhibition, adenosine A1. | This one works differently. As well as acting at receptors itself, it slows the removal of anandamide, the cannabinoid her own body makes, so more of what she already produces stays in circulation. Adenosine A1 is the pathway associated with settling and with sleep. |
The evidence behind each decision, and where it stops
Every source that supports the formulation and the route, with the limit on it stated alongside. The right hand column is the part that matters. No brand in section 5 publishes a limitation, and a document that cites papers without stating what they do not show is doing the same thing.
B1. Receptors in the tissue we deliver into
| Source | What it found | What it lets us say | The limit on it |
|---|---|---|---|
| Wright and colleagues Gastroenterology | Intense CB1 expression in human colonic epithelium and in the submucosal nerve plexuses, and CB2 expression in the immune cells beneath the surface. | CB1 and CB2 are demonstrated in human colorectal tissue. Peer reviewed, human, in the tissue we deliver into. | None material. This is the load bearing citation for the route. |
| Human Protein Atlas Protein expression records | CB1 protein high in rectal glandular cells and not detected in vaginal squamous epithelium. CB2 high in the rectum and low in the vagina. | The receptors are present where we deliver. We do not claim they are absent elsewhere. | The Atlas rates its own CB2 antibody staining as uncertain, and its transcript data points the other way. Use the positive statement only. |
| El-Talatini and colleagues 2009 | CB1 and CB2 receptors present in human ovarian tissue. | The system we are acting on is present in the reproductive organs themselves, in human tissue. | Presence, not function. It shows the receptors are there, not what happens when something binds them. |
| Standard anatomy Inferior hypogastric plexus | The rectum, bladder and uterus are innervated together by the inferior hypogastric plexus. | Placing a formulation in the rectum puts it alongside the nerve supply that also serves the uterus. | The plexus is paired and sits in the pelvic sidewall fascia sending branches to the rectum, not flat against the rectal wall. A competent reader will check. |
| Neuronal tracing Dual innervating neurons | Individual sensory neurons innervate the uterus and the colon at the same time, and those neurons carry TRPV1. | There is a real, repeatedly replicated mechanism by which pelvic organs refer sensation to each other. | Done in rats, and the dual innervating neurons were three to fifteen per cent of the population depending on the segment. It is not most of the wiring. |
| Pooled analysis Endometriosis and IBS, eleven studies | Women with endometriosis are roughly three times as likely to have irritable bowel syndrome. Pooled odds ratio 2.97, confidence interval 2.17 to 4.06. | The two organs are wired together and they behave that way in the clinic, not only in the anatomy. | An association across two conditions. It supports the shared innervation argument, it does not prove a treatment route. |
B2. The pharmacological gap between their formulation and ours
| Source | What it found | What it lets us say | The limit on it |
|---|---|---|---|
| TRP channel screen Phytocannabinoids across the TRP family | Cannabidiol has no published agonist activity at TRPV4. At TRPV1 it is a partial agonist of modest potency, roughly 1 to 3.5 micromolar at about half to two thirds of maximum, and on sustained exposure it desensitises the channel faster than it activates it. | The single molecule this entire category is built on does not reach TRPV4 and reaches TRPV1 weakly. That is the pharmacological gap between their product and ours. | Cell assays in engineered cells, several using the rat form of the channel. |
| Same screen The compounds that do reach those channels | TRPV4 is reached by CBG, CBGA and CBN. At TRPA1 the most potent and most selective is CBC, at 0.09 micromolar, and the largest response belongs to CBGA at 182.8 per cent efficacy. | We carry CBG, CBGA, CBN and CBC alongside cannabidiol, which puts TRPV4 in play and raises the ceiling at TRPA1. We claim coverage of targets. | CBC loses most of its potency in real neurons. And nobody has tested this combination as a combination, so we never claim a proven combined effect. |
| Receptor binding Cannabidiol at CB1 and CB2 | Cannabidiol has negligible affinity for the main binding site on CB1 and CB2, and acts at CB1 as a negative allosteric modulator, adjusting how the receptor responds rather than switching it on. | An entire category is built on one molecule that binds the cannabinoid receptors weakly. It is also why our product does not intoxicate. | It is a fair description of cannabidiol, not a criticism of it. Most of its useful pharmacology is at non cannabinoid targets. |
| Anderson and colleagues Scientific Reports | CBG and THC inhibit the BCRP efflux pump, and plasma cannabidiolic acid was fourteen times higher given in a whole extract than given alone. The authors call it a mechanism for the entourage effect. | Cannabinoids raise each other's blood levels, which is a published mechanism for why a broad profile is not simply a longer ingredient list. | Done in mice, and the cannabinoid measured was CBDA rather than CBD. Say both whenever this is used. |
| Linares and colleagues 2019, placebo controlled | In fifty seven healthy men, cannabidiol at 300 milligrams reduced anxiety in a simulated public speaking test while 150 and 600 milligrams did not. | Dose response is an inverted curve. What matters is reaching the right targets, not overwhelming one. This is the answer to why not simply more cannabidiol. | No women were included, which matters given who we sell to. |
B3. Why the route is rectal and not vaginal
| Source | What it found | What it lets us say | The limit on it |
|---|---|---|---|
| Human Microbiome Project Huse and colleagues | The vagina had the lowest diversity of the eighteen body sites sampled. Shannon diversity index 0.071 at the posterior fornix against 2.655 in saliva. | The vaginal community is a monoculture whose defence rests on one genus holding pH between 3.5 and 4.5. Remove it and nothing equivalent takes over. | Say lowest of the sites measured, not lowest on the body. It holds for Lactobacillus dominant communities rather than for all women. |
| Blaskovich and colleagues Communications Biology | Cannabidiol active against Staphylococcus aureus at 4 micrograms per millilitre, Enterococcus faecalis at 1 to 4, and beta haemolytic streptococci at 8 to 32. Largely inactive against Gram negatives, with Neisseria the exception at 1 to 2. | Cannabinoid antibacterial activity is concentrated on Gram positive organisms, at concentrations a suppository creates locally. | None for the general claim. The specific application to vaginal species is inference, set out below. |
| Antibiotics 2025 | Cannabidiol killed Gardnerella vaginalis at 2.5 micrograms per millilitre, with 1.25 preventing biofilm formation. Clearing an established biofilm took 2.5 for a seventy eight to eighty per cent reduction and 5 to 10 for eighty eight to ninety. | Cannabinoids are active against vaginal organisms at achievable local concentrations. This is a demonstrated effect in the vaginal niche, not a general one. | Gardnerella is the organism you want killed. The paper does not tell us what happens to the ones you do not. |
| The gap in the literature Vaginal Lactobacillus species | We could find no published study measuring a cannabinoid concentration against Lactobacillus crispatus, gasseri, jensenii or iners. These are Gram positive Lactobacillales, the same order as Streptococcus and Enterococcus. | There is no published basis for assuming vaginal lactobacilli are spared. We chose the route that does not need the question answered. | The absence of data is symmetrical. Nobody has shown these organisms are harmed. A competitor can say that as easily as we say ours. |
| Journal of Clinical Microbiology | Lactobacilli physiologically absent in 2.1 per cent of fertile women, 11.4 per cent of perimenopausal women and 44.1 per cent of postmenopausal women not taking hormones. | Nearly half of the women we serve have already lost the protective organism. They have less margin than any other group. | None. This is our customer described precisely, and it is the strongest version of the route argument. |
| New England Journal of Medicine 1993 | Restoring lactobacilli with vaginal oestrogen cut recurrent urinary tract infections from 5.9 to 0.5 episodes per patient year. | The vagina is the staging post for urinary infection. The rectum is not. | One trial, and later pessary studies were less impressive. |
| American cohort study Cannabis and bacterial vaginosis | Cannabis use was associated with recurrent bacterial vaginosis at an adjusted odds ratio of 2.05. | Nothing in our favour. It is here because a careful reader will raise it and we should raise it first. | Smoked cannabis, not a suppository. It proves nothing about our formulation either way. |
B4. Tolerability of the route, and dose
| Source | What it found | What it lets us say | The limit on it |
|---|---|---|---|
| Naftali and colleagues Inflammatory Intestinal Diseases, 2026 | Fourteen adults with refractory ulcerative proctitis given a daily fifty millilitre rectal enema of sixty milligrams cannabidiol with seventy milligrams sodium propionate for twelve weeks. Nine of fourteen completed. Clinical response fifty per cent intention to treat and seventy seven per cent among completers, with no treatment related serious adverse events. | Daily rectal cannabinoid dosing into actively inflamed human tissue was tolerated across twelve weeks. It answers the first question a careful woman or clinician asks. | An enema, not a suppository, and not cannabidiol alone. Cite it for tolerability of the route and never for efficacy. |
| Cochrane review Non steroidal anti inflammatories for period pain | Eighty randomised trials in 5,820 women. The drug class is effective, on evidence the review rated low quality. | Rectal delivery is established clinical practice in this field. We did not invent the route. | The review does not confirm which routes its trials used, so we never name specific rectal drugs alongside it. |
| Two placebo controlled trials Vaginal muscle relaxant for pelvic floor pain | The vaginal route was tested with a well characterised muscle relaxant and failed in both. | A caution against assuming vaginal placement works simply because it is local. | Both were small, and one drug failing by one route is not the route failing. That is all we take from it. |
| Vaginal innervation density | On the anterior vaginal wall the distal third carries significantly more nerve fibres than the proximal third. The posterior wall shows no such gradient. | A vaginal suppository sits proximally, which on the anterior wall is the sparser end. | A supporting point, not a decisive one. |
B5. The endocannabinoid system in women, and why the evidence is thin
| Source | What it found | What it lets us say | The limit on it |
|---|---|---|---|
| Two human datasets 184 women, and 700 across the lifespan | Circulating endocannabinoid levels rise around and after menopause. | Her hormones change and the system alongside them measurably moves with them. Something is already happening there. | This contradicts the intuitive depletion story. Any education we write has to be built on the movement, not on a deficit. |
| Historical record United States Pharmacopeia | Cannabis preparations were listed from 1850 and sold by Eli Lilly, Parke-Davis, Squibb and E. Merck of Darmstadt. The Marihuana Tax Act of 1937 began the end of it and the monographs were removed in 1942. The University of Mississippi was the only federally authorised source of research cannabis until 2021. | The modern trial literature is thin because of that history, not because nobody was interested. It is the answer to why is there not more evidence. | History, not evidence of effect. It explains an absence, it does not fill it. |
Nothing in these tables is a claim of therapeutic effect and none of it may be restated as one. Receptor pharmacology says where a compound acts. It does not say what happens to a woman. Where a row supports reasoning rather than a finding, the middle column says so, and any public use of that row has to say so too.